Sonochemical synthesis and characterization of Fe(II) and Cu(II) nano-sized complexes of sulfamethoxazole

Authors

  • B. C. Asogwa Department of Chemistry, Michael Okpara University of Agriculture Umudike, Abia State
  • I. E. Otuokere Department of Chemistry, Michael Okpara University of Agriculture Umudike, Abia State

Keywords:

sulfamethaxazole, nano metal complexes, FTIR, XRD, NMR

Abstract

Nanoparticle drug delivery systems are precisely designed technologies that utilize nanoparticles to deliver therapeutic drugs to specific targets and regulate their release. In recent times, nanoparticles have garnered significant interest owing to their potential for efficient drug delivery. This work is aimed at synthesizing Fe(II) and Cu(II) nano-sized complexes of sulfamethoxazole (SMX) using the sonication method. The physical and spectroscopic studies showed a colour change from white to grey, and a decrease in melting points suggested the formation of the metal complexes. The nanometal complexes were insoluble in water. XRD analysis showed that the crystallite sizes of Fe(II) and Cu(II) nanometal complexes were determined to be 76.08 nm and 37.13 nm, respectively, using the Debye-Scherrer equation. The FTIR results of the SMX, Fe(II), and Cu(II) nanometal complexes showed a shift of the amine band from 3243 to 3191 cm^-1 and the sulfone band from 1154 to 1092 cm^-1 in both complexes. The proton NMR showed a shift of the amine proton from 6.100 ppm to 6.035 ppm in the spectra of the Cu(II) complex. The amine chemical shift was absent in the spectra of the Fe(II) complex, showing deprotonation. The carbon-13 NMR spectra showed a similar chemical shift. The spectra studies indicated that SMX coordinated with the metal ions through the amino and sulfone groups. A tetrahedral structure was proposed for the complexes. SMX coordinated as a bidentate ligand to Fe(II) and Cu(II) ions.

Author Biography

I. E. Otuokere, Department of Chemistry, Michael Okpara University of Agriculture Umudike, Abia State

Proffessor of Inorganic Chemistry

Dimensions

X. Chen, H. Li, X. Qiao, T. Jiang, X. Fu, Y. He & X. Zhao, “Agarose oligosaccharide- silver nanoparticle- antimicrobial peptidecomposite for wound dressing”, Carbohydrate Polymer 269 (2021) 118258. https://www.sciencedirect.com/science/article/abs/pii/S0144861721006457.

M. J. Khan, A. Ahmad, M. A. Khan & S. Siddiqui, “Zinc Oxide Nanoparticle Induces Apoptosis in Human Epidermoid Carcinoma Cells Through Reactive Oxygen Species and DNA Degradation”, Biological Trace Element Research 199 (2021) 2172.

https://link.springer.com/article/10.1007/s12011-020-02323-4.

P. Redruello, G. Perazzoli, A. Cepero, F. Quinonero, C. Mesas, K. ˜Doello, A. Lainez-Ramos- Bossini, M. Rivera-Izquierdo, C. Melguizo & J. Prados, “Nanomedicine in Pancreatic Cancer: A New Hope for Treatment”, Current Drug Targets 21 (2020) 580. https://doi.org/10.2174/1389450121666200703195229.

I. E. Otuokere, J. C. Anyanwu, & K. K. Igwe, “Synthesis, Characterization and Antibacterial Studies of 4-{[(E)- Phenylmethylidene] amino}-N-(1,3-thiazol-2- yl)benzenesulfonamide and its Mn(II) Complex”, Chemsearch Journal 11 (2020) 44. https://www.ajol.info/index.php/csj/article/view/197378.

I. E. Otuokere, J. G. Ohwimu, K. C. Amadi, C. O. Alisa, F. C. Nwadire, O. U. Igwe, A. A. Okoyeagu & C. M. Ngwu. ”Synthesis, characterization and molecular docking studies of Mn (II) complex of sulfathiazole”, Journal of the Nigerian Society of Physical Sciences 1 (2019) 95. https://journal.nsps.org.ng/index.php/jnsps/article/view/20.

I. E. Otuokere, D. O. Okorie, B. C. Asogwa, O. K. Amadi, L. O. C Ubani & F. C. Nwadire, “Spectroscopic and Coordination Behavior of Ascorbic Acid Towards Copper (II) Ion”, Research in Analytical and Bioanalytical Chemistry 1 (2017) 1. https://www.academia.edu/35242668/Spectroscopic_and_Coordination_Behavior_of_Ascorbic_Acid_Towards_Copper_II_Ion.

V. V. Shalygina, E. N. Vlasova & E. P. Anan’eva, “Synthesis, Physicochemical Properties, and Antimicrobial Activity of Polymyxin B1 Conjugates with Polyglutaraldehyde”, Pharmceutical Chemistry Journal 53 (2019) 134. https://doi.org/10.1007/s11094-019-01967-4.

H. Sirajul, S. Dildar, M. B. Ali, A. Mezni, A. Hedfi, M. I. Shahzad, N. Shahzad & A. Shah, “Antimicrobial and antioxidant properties of biosynthesized of NiO nanoparticles using Raphanus sativus (R. sativus) ex tract”, Journal of Inorganic and Organometallic Polymers and Materials 31 (2020) 1134. https://iopscience.iop.org/article/10.1088/2053-1591/abfc7c/meta.

I. O. Edozie, O. J. Godday, A. K. Chijioke, I. O. Uchenna, & N. F. Chigozie, “Synthesis, characterization and molecular docking studies of Co (II) metal complex of sulfathiazole”, Bulletin of the Chemical Society

of Ethiopia 34 (2020) 83. https://dx.doi.org/10.4314/bcse.v34i1.8.

I. E. Otuokere, U. F. Robert & K. K. Igwe, ”Chelating and Antibacterial Potentials of Benzylpenicillin and its Ni (II) Complex”, Communication in Physical Sciences 8 (2022) 138. https://journalcps.com/index.php/volumes/article/view/269.

I. E. Otuokere, U. F. Robert, K. K. Igwe & S. U. Mpama, “Synthesis, Characterization and Antibacterial Studies of Benzylpenicillin and its Co(II) Complex”, ChemSearch Journal 11 (2020) 9.

https://www.ajol.info/index.php/csj/article/view/197367.

I. E. Otuokere, K. C. Nwaiwu, F. C. Nwadire, and O. U. Akoh, ”Synthesis and characterization of Cr (III)-ascorbic acid complex” Journal of Applied Sciences and Environmental Management 26 (2022) 75. https://dx.doi.org/10.4314/jasem.v26i1.12.

N. V. Loginova, H. I. Harbatsevich, N. P. Osipovich, G. A. Ksendzova, T. V. Koval’chuk & G. I Polozov, “Metal Complexes as Promising Agents for Biomedical Applications”, Current Medicinal Chemistry 27 (2020) 5213. https://doi.org/10.2174/0929867326666190417143533.

I. E. Otuokere, L. O. Okpara, K. C. Amadi, N. Ikpo, G. U. Okafor & F. C. Nwadire, “Synthesis, Characterization And Complexation Of Cr(III) Ion Using Chloroquine Diphosphate Drug”, Journal of Chemical Society of Nigeria 44 (2019) 107.

https://nijophasr.net/index.php/nijophasr/article/view/274.

M. P. Nikolova, & M. S. Chavali, “Metal oxide nanoparticles and their applications in nanotechnology”, SN Applied Resources 1 (2020) 607.

https://link.springer.com/article/10.1007/s42452-019-0592-3.

H. Chou-Yi , M. R. Ahmed, M. K. Mustafa, N. A. Nada, H. M. Srwa, H. A. Fatima, T. A. Zainab, M. A. Zahra, S. A. Zainab, K. H. Safa, K. A. Farah, H. M Zaid & K. Ehsan, “ An overview of nanoparticles in drugdelivery: Properties and applications”, South African Journal of Chemical Engineering 46 (2023) 233. https://doi.org/10.1016/j.sajce.2023.08.009.

G. Prasannamedha & P. S. Kumar, “A review on contamination and removal of sulfamethoxazole from aqueous solution using cleaner techniques: Present and future perspective”, Journal of Cleaner Production 250 (2020) 119553. https://doi.org/10.1016/j.jclepro.2019.119553.

J. S. Geraldine, N. N. Delgado, R. Maharjan & A. K. Cain, “How antibiotics work together: molecular mechanisms behind combination therapy”, Current Opinion in Microbiology 57 (2020) 31. https://doi.org/10.1016/j.mib.2020.05.012.

A. Ovung & J. Bhattacharyya, “Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions”, Biophysical Reviews 13 (2021) 259. https://link.springer.com/article/10.1007/s12551-021-00795-9.

J. L. Siqueira-Neto, K. J. Wicht, K. Chibale, J. N. Burrows, D. A. Fidock & E. A. Winzeler, “Antimalarial drug discovery: progress and approaches”, Nat Rev Drug Discovery 22 (2023) 807. https://doi.org/10.1038/s41573-023-00772-9.

M. Samsonowicz, M. Kalinowska & K. Gryko, “Enhanced antioxidant activity of Ursolic acid by complexation with Copper (II): experimental and theoretical study”, Materials 14 (2021) 264. https://doi.org/10.3390/ma14020264.

M. M. Abdul-Hassan & N. K. Mousa, Antimicrobial activity of new transition metal complexes of sulfamethoxazole on nhibiter by Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi and Escherichia coli, In AIP Conference Proceedings, 2020, AIP Publishing, 2290. https://pubs.aip.org/aip/acp/article/2290/1/030037/1001400/Antimicrobial-activity-of-new-transition-metal.

S. Rostamizadeh, Z. Daneshfar & H. Moghimi, “Synthesis of sulfamethoxazole and sulfabenzamide metal complexes; evaluation of their antibacterial activity”, European Journal of Medicinal Chemistry 171 (2019) 364. https://doi.org/10.1016/j.ejmech.2019.03.002.

N. Zare, A. Zabardasti, A. Mohammadi, “Sonochemical synthesis, characterization, biological applications, and DFT study of new nano-sized manganese complex of azomethine derivative of diaminomaleonitrile”, Journal of Iran Chemical Society 16 (2019) 1501.

https://doi.org/10.1007/s13738-019-01626-1.

O. Ugochukwu & I. E. Otuokere, ”Synthesis, Spectroscopic Characterization and Antibactrial Activities of Co (II) Complex of Ofloxacin Drug Mixed with Ascorbic Acid as a Secondary Ligand”, BioScientific Review 3 (2021) 1. https://doi.org/10.32350/BSR.0303.01.

S. J. Almehmadi, A. Alharbi, M. M. Abualnaja, K. Alkhamis, M. Alhasani, S. H. Abdel-Hafez, R. Zaky & N. M. El-Metwaly, “Solvent free synthesis, characterization, DFT, cyclic voltammetry and biological assay of Cu(II), Hg(II) and UO2(II) – Schiff base complexes”, Arabian Journal of Chemistry 15 (2022) 103586. https://doi.org/10.1016/j.arabjc.2021.103586.

A. Al-Rsheed, S. Aldawood & O. Aldossary, “The Size and Shape Effects on the Melting Point of Nanoparticles Based on the Lennard-Jones Potential Function”, Nanomaterials (Basel) 30 (2021) 2916. https://www.mdpi.com/2079-4991/11/11/2916.

S. Sarala, S. K. Geetha, S. Muthu & A. Irfan, “Theoretical investigation on influence of protic and aprotic solvents effect and structural (Monomer, Dimer), Van-der Waals and Hirshfeld surface analysis for clonidine molecule”, Computational and Theoretical Chemistry 1204 (2021) 113397. https://doi.org/10.1016/j.comptc.2021.113397.

M. H. Genc¸kal, M. Erkisa, P. Alper, S. Sahin, E. Ulukaya & F. Ari, “Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and antioxidant activity”, Journal of Biological Inorganic Chemistry 25 (2020) 161. https://doi.org/10.1007/s00775-019-01749-z.

I. E. Otuokere & U. F. Robert, ”Synthesis, Characterization and Antibacterial Studies of (3, 3- Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo [3.2. 0]heptane-2-carboxylic acid-Cr (III) Complex”, Journal of Nepal Chemical Society 41 (2020) 1.

https://doi.org/10.3126/jncs.v41i1.30370.

A. Kotynia, B. Wiatrak, W. Kamysz, D. Neubauer, P. Jawien & A. Marciniak, “Cationic Peptides and their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics”, International Journal of Molecular Science 22 (2021) 12028. https://doi.org/10.3390/ijms222112028.

M. O. Bamigboye, J. A. Obaleye & S. Abdulmolib, “Synthesis, characterization and antimicrobial activity of some mixed Sulfamethoxazolecloxacillin metal drug complexes”, International Journal of Chemistry 22 (2012) 105. https://www.researchgate.net/publication/275039892_Synthesis_Characterization_and_Antimicrobial_Activity_of_SomeMixed_Trimethoprim_Metal_Drug_Complexes.

 Proposed structure for [Fe(SMX)(H2O)2]

Published

2024-06-19

How to Cite

Sonochemical synthesis and characterization of Fe(II) and Cu(II) nano-sized complexes of sulfamethoxazole. (2024). Journal of the Nigerian Society of Physical Sciences, 6(3), 2011. https://doi.org/10.46481/jnsps.2024.2011

How to Cite

Sonochemical synthesis and characterization of Fe(II) and Cu(II) nano-sized complexes of sulfamethoxazole. (2024). Journal of the Nigerian Society of Physical Sciences, 6(3), 2011. https://doi.org/10.46481/jnsps.2024.2011